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投稿时间：2020-04-21
投稿时间：2020-04-21
中文摘要: 以光损伤小鼠为模型，分别用230、300、380 mg/kg bw剂量的菊花粗提物对小鼠进行8周干预，探讨菊花粗提物对光损伤小鼠晶状体及肝脏抗氧化能力的影响。结果显示，通过比较晶状体中谷胱甘肽过氧化物酶（glutathione peroxidase，GSH-Px）活力和总抗氧化能力（total antioxidant capacity，T-AOC）发现，菊花粗提物干预组GSH-Px活力与T-AOC明显高于模型组，菊花粗提物剂量组与模型组比较均具有显著差异（P＜0.05），其抗氧化效能随着粗提物剂量的增大而升高。肝脏抗氧化评价结果显示，菊花粗提物高剂量组的抗氧化效果优于低剂量组，呈剂量依赖性；与模型组相比，菊花粗提物各剂量组抗氧化指标均具有显著差异（P＜0.05）。结果表明，菊花粗提物可以增强小鼠晶状体和肝组织的抗氧化能力，可能对氧化应激诱导的视疲劳具有缓解作用。
Abstract:The light damaged mice were used as the model，the doses of 230，300，380 mg/kg bw crude extract of chrysanthemum was used to intervene the mice，to explore the effect that crude extract of chrysanthemum on the anti-oxidation ability of lens and liver of light damaged mice.The results of glutathione peroxidase（GSH-Px）activity and total antioxidant capacity（T-AOC）showed that the GSH-Px activity and T-AOC of the intervention group were significantly higher than those of the model group.The antioxidant effect of the intervention group was significantly higher than that of the model group （P＜0.05）.From the antioxidant index of liver，the antioxidant effect of the high dose group was better than that of low dose group，which was dose-dependent.Compared with the model group，the antioxidant indexes of the low，middle and high dose groups of crude extract were statistically different（P＜0.05）.The results showed that crude extract of chrysanthemum could enhance the antioxidant capacity of mouse lens and liver tissue，suggesting that crude extract of chrysanthemum might have a relieving effect on oxidative stress-related visual fatigue.
keywords: chrysanthemum light damage antioxidant lens liver
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