Abstract:To investigate the difference of anthocyanins exstracted from black rice and European bilberry about anti-oxidation and effect on function of liver in vivo，low，middle and high dosage of anthocyanins extracted from black rice and European bilberry were fed to mice via intragastric administration.Then the activity of aspartate aminotransferase（AST），alanine aminotransfease（ALT），superoxide dismutase（SOD），catalase（CAT）and total antioxidant capability （T-AOC）in serum of mice were determined，and the activity of SOD，glutathione peroxidase （GSH-Px）and concentration of malondialdehyde （MDA）in liver were measured.Results showed that anthocyanins extract from black rice and European bilberry could significantly enhance the level of SOD，CAT，T-AOC in serum of mice，and decrease the concentration of AST，ALT.At low dosage，anthocyanins extract from black rice was significant enhanced the activity of T-AOC than European bilberry（P<0.05）.Compared with control group，black rice and bilberry anthocyanins extract could significantly increase SOD and GSH-Px activity and decrease MDA content of liver（P<0.05）.At low dosage，anthocyanins extract from black rice was significant enhanced the activity of GSH-Px than European bilberry（P<0.05）.Totally，the anthocyanins extract from black rice and European bilberry can protect liver function via increasing antioxidant activity in mice，and at low dosage，the anthocyanins extract from black black rice play better antioxidant.