Abstract:To optimize the ultrasonic-assisted extraction technology of proanthocyanidins from the Ligustrum lucidum ait by box-behnken response surface methodology.The single-facotr experiment and response surface methodology were adopted to study the effects of extraction time，ultrasonic power，liquid-solid ratio and ethanol concentration on the extraction yield of proanthocyanidins from Ligustrum lucidum ait.Then the antioxidant activities of proanthocyanidins were evaluated by pyrogallol autoxidation，DPPH and salicylic acid（SA）methods.The results showed that the optimal extraction technology for proanthocyanidins were as following，extraction time was 33 min，ultrasonic power was 400 W，liquid-solid ratio was 27∶1（mL/g），and ethanol concentration was 50%.Under optimal technology，the extraction yield of proanthocyanidins was about（2.85±0.06）%.When the concentration of proanthocyanidins was 1.0 mg/mL，the maximum scavenging rate of DPPH radicals reached to 97%，the maximum clearance rate of superoxide anions reached to 60.14%，and the scavenging rate of flavonoids to hydroxyl radicals was 78.88%.The optimal extraction technology of proanthocyanidins from the Ligustrum lucidum ait was reasonable，stable，feasible and the proanthocyanidins had good antioxidant activity.