Abstract:Based on the stability of amino group in cordycepin，the amino group of cordycepin was modified and cordycepin was hybridized with magnetic materials.N-acryloyl cordycepin was a new compound，which was synthesized with acryloyl chloride as acylating agent，triethylamine as acid-binding agent，and it was characterized by high resolution mass spectrometry，nuclear magnetic resonance spectra，it reacted with 3-aminopropyl triethoxysilane in template reaction to obtain N-[1-oxopropanyl-3-（3-（triethoxysilyl）propyl）amino]cordycepin.Then，the aza-Michael reaction of N-acryloyl cordycepin with amino magnetic material（Fe3O4-NH2）occurs.The hybridization product was proved to be Fe3O4-NH2@N-acryloyl cordycepin by means of X-ray powder diffraction，magnetic moments and ninhydrin colorimetry.Thus，N-acryloyl cordycepin was potential active intermediate because of its antimicrobial activity，hybridization with inorganic materials capacity.