Abstract:The anti-oxidation and anti-aging effects of wild Oplopanax elatus Nakai.（CRS）in Changbai Mountain were studied.The conditions of DPPH were determined by microplate method.The anti-oxidation effect of CRS in vitro was investigated.The biological model of drosophila was used as the object of investigation.The effects of different concentrations of acanthopanax ginseng on the longevity related behavioral indexes of drosophila melanogaster and MDA content and SOD activity of exhausted swimming mice were determined.The in vitro results showed that the optimal reaction time for DPPH free radical scavenging by microplate method was 30 min，the reaction volume was 1 ∶1，and the IC50 value of DPPH free radical scavenging rate of CRS was 0.829 mg/mL，the positive control Vitamin C had an IC50 value of 0.040 1 mg/mL.The results of in vivo experiments showed that the ginseng lyophilized powder could prolong the lifespan of Drosophila，increase the number of offspring of Drosophila，improve the climbing ability of the old fly，and improve the anti-acute oxidative damage and water content of the old Drosophila，and it could reduce MDA content and improve SOD activity.Changbai Mountain wild CRS had anti-oxidation and anti-aging effects in vitro and in vivo，and could improve the life-related indicators of fruit flies.