Abstract:Phellinus igniariushas become a research hotspots of function food due to its anticancer function，Now，it is the highest efficiency anticancer fungi in biological field.Ultrasonic-microwave synergistic assisted extraction of polysaccharides from Phellinus igniarius was proposed.The optimal conditions of extraction time，solvent-to-solid ratio，ultrasonic power and microwave power for extracting polysaccharides from Phellinus igniariushas were studied，respectively.The combined use of ultrasonic and microwave provided a time-saving and high-yield method for polysaccharides assisted extraction from Phellinus igniarius.The antioxidant and antitumor activity of the polysaccharides from Phellinus igniarius were studied，the polysaccharides had very strong antioxidant ability，and it had strong toxicity to the human hepatoma cell and human cervical carcinoma cell.The polysaccharides extracted by ultrasonic microwave assisted method exhibit higher activity.The results showed the method was not only efficient，but also can improve the activity of polysaccharides.