Abstract:A compound calcium chewable tablet for pregnant women was developed.Definitive screening design（DSD）was used to screen and optimize the amount of excipients，wet granulation and total mixing process.The amount of excipients and the optimum process were determined.The optimum dosage of excipients was 2.00 %carboxymethyl cellulose sodium，2.00%polyvinyl ketone K30 and 10.00%polyvinyl ketone aqueous solution.Wet granulation，vitamin D3 and folic acid were used to mix.The product had sweet taste，suitable fragrance and hardness.The content of calcium，iron，copper，folic acid and vitamin D3 was even，the quality was stable，and it was easy to be industrialized.