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投稿时间：2018-09-28
投稿时间：2018-09-28
中文摘要: 阿尔兹海默症复杂的发病机制，使得其防治成为了目前研究的一大难点。膳食多酚因其具有良好的生物活性，且来源广泛、结构多样、毒性低等特点，受到广泛关注。研究表明，膳食多酚能够对自由基损伤、胆碱能损伤、β-淀粉样蛋白（amyloid β-protein，Aβ）神经毒性、Tau 蛋白磷酸化、神经炎症等多种发病机制进行干预。因此，结合最新的研究进展对阿尔兹海默症的发病机制及其防治进行简单介绍，对姜黄素、表没食子儿茶素没食子酸酯和白藜芦醇等膳食多酚对阿尔兹海默症的作用机制进行综述。最后，在此基础上提出了膳食多酚防治阿尔兹海默症的研究方向，以期为天然产物功能性基础研究提供理论和应用依据。
Abstract:The complex pathogenesis of Alzheimer's disease makes its prevention and control a major difficulty in current research.Dietary polyphenols have attracted wide attention due to their good biological activity，wide source，diverse structure and low toxicity.Studies have shown that dietary polyphenols can interfere with many pathogenesis such as free radical damage，cholinergic damage，amyloid β-protein neurotoxicity，Tau protein phosphorylation，and neuroinflammation.Therefore，this article summarized the pathogenesis and prevention of Alzheimer's disease with the latest research progress，focused on the mechanism of action of curcumin，epigallocatechin gallate and resveratrol on Alzheimer's disease.Based on this，it proposed the research direction of dietary polyphenols in preventing and treating Alzheimer's disease.The purpose was to provide theory and application basis for functional basic research of natural products.
keywords: Alzheimer's disease pathogenesis dietary polyphenols curcumin epigallocatechin gallate eesveratrol
文章编号：201911037 中图分类号： 文献标志码：
基金项目:国家自然科学基金面上项目（31270722）
| Author Name | Affiliation |
| WANG Wei，YE Qian-zhen，WU Xiao-qin，CHEN Yu-feng，SHEN Jian-fu* | College of Biosystem Engineering and Food Science，Zhejiang University，Hangzhou 310058，Zhejiang，China |
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