Abstract:With hawthorn as raw material，the process of microwave assisted extraction of organic acids by ionic liquid enzyme method was optimized by response surface test.In ionic liquids，ionic liquid dosage，cellulase concentration，solid-liquid ratio and time as independent variables，organic acid content in hawthorn as response value，optimize the Hawthorn organic acid the best extraction conditions were：bromide ionic liquid Ding Jisan -1-methyl imidazole concentration was 0.039 mol/L，the adding amount of cellulase concentration was 1.059%，liquid-solid ratio of 29.84∶1 （mL/g），extraction temperature 55 ℃，extraction time 25.3 min，organic acid content under this condition was 164.159 mg/g.The organic acids obtained by the two methods of traditional water immersion method and ionic liquid enzymatic method were analyzed by high performance liquid chromatography （HPLC）.The main components were citric acid，which accounted for 88.641%and 90.858%of the relative content.Compared with the traditional water immersion method，the ionic liquid enzyme method effectively shortened the extraction time.