Abstract:The physicochemical properties and functional effects of the skin pigment of the giant salamander were studied.The skin pigment was extracted，purified by alkali solution acid precipitation method.After collection，the giant salamander skin pigment was analyzed qualitatively by the ultraviolet-visible and infrared spectroscopy and their stability，antioxidant，anti-ultraviolet and antimicrobial effects were determined.The results showed that the maximum ultraviolet absorption peak of the skin pigments of giant salamander was 214 nm，which was a sulfur-containing isomer with indole structure.It had good photostability and thermal stability，and was greatly affected by iron ions.It had obvious absorption effect on ultraviolet radiation，and had certain scavenging effect on hydroxyl radicals and superoxide anions.At the same time，the skin pigments of giant salamander had obvious inhibitory effect on Escherichia coli and had certain health function.