Abstract:In order to investigate the effect of Guimu Chunlu（GMCL）on antialcoholism and liver protection in mice，100 male mice were randomly divided into model group，positive drug control group（0.15 mL/10 g），GMCL high，medium and low dose groups（0.2，0.15，0.1 mL/10 g）.The mice were administrated 0.15 mL/10 g ethanol，the latent time of drunkenness and the durative time of drunkenness were calculated in all groups.Mice were administrated the related drugs for 14 d，the activities of serum ALT（aspartate aminotransferase）and AST（alanine aminotransferase），the content of MDA（malondialdehyde）and SOD（superoxide dismutase）in liver were measured.And the liver index was calculated.The results showed that GMCL could significantly（P<0.05 or P<0.01）postpone the tolerance time of mice to the alcohol，and shorten the duration of drunkenness obviously. GMCL could markedly decrease the activities of AST and ALT，the level of MDA and liver index，increase the activities of SOD （P<0.05 or P<0.01）. It showed that GMCL had beneficial effects on preventing drunkenness and relieving alcoholism.It could reduce liver injury induced by ethanol in mice.