Abstract:Abstract：In order to obtain a more efficient method for extracting polyphenols from Rhamnus davurica Pall.，the content of polyphenols was determined by Folin phenol colorimetric method with Rhamnus davurica Pall.as raw material and ethanol as solvent.On the basis of single factor study on the effects of ultrasonic time，ultrasonic power，liquid-to-solid ratio and ethanol concentration on the extraction of polyphenol from Rhamnus davurica Pall.，the response surface optimization of polyphenol extraction from Rhamnus davurica Pall.was optimized by using ultrasonic-assisted method.Draw the best extraction process conditions：the ultrasound time 43 minutes，the ultrasonic power was 550 W，the liquid-to-solid ratio was 15 ∶1（mL/g），the ethanol concentration was 52%，then the Rhamnus davurica Pall.polyphenols extract amount was（6.23±0.18）mg/g.