Abstract:Abstract：The objective of this work was to explore the antioxidant capacities in vivo of Rehmannia glutinosa polysaccharides in mice.Kunming mice were selected as the experimental animals.The mice in three dose groups were supplied with different dosage of increased Rehmannia glutinosa polysaccharides（150，300，550 mg/kg）by intra-gastric administration daily for different days （14，21，28 d）.Mice body weight and the activity of superoxide dismutase and glutathione peroxidase from each group were monitored.The content of malondialdehyde was also determined.Results indicated that continuous administration of different doses of Rehmannia glutinosa polysaccharides had no effect on body weight in mice，but the activity of superoxide dismutase and glutathione peroxidase from liver and serum were higher（P＜0.05）than the control，and the content of malondialdehyde in liver and serum had a marked reduction effect（P＜0.05）.All the above effects were obvious in middle and high dose group mice.Taken together，the results of this study suggested that polysaccharides from Rehmannia glutinosa could be used as novel potential antioxidants.