Abstract:Calcium is the most abundant inorganic element in human body，which plays an important role in intracellular metabolism，bone growth，blood clotting，nerve conduction，muscle contraction，and cardiac function.Calcium deficiency pose a great threat to human health.As a by-product of aquatic products processing，fish bone is a rich calcium source.The preparation of calcium from fish bone has the advantages of sufficiency of resources，low price，good quality and stability，and high absorptivity，which realizes the efficient utilization of fish bone and reduces the pressure of environmental pollution.The present situation of fish bone calcium in food science was introduced from the following aspects：absorption mechanism of fish bone calcium，comprehensive utilization，various preparation methods and calcium chelating composites preparation.In addition，the paper also explored the development of fish bone calcium in the field of food and provided reference for the further research and utilization of fish bone calcium in the future.