本文已被：浏览 7910次 下载 0次
投稿时间：2018-06-27
投稿时间：2018-06-27
中文摘要: 采用高压静电场法制备壳聚糖－L-苯丙氨酸微囊。以包封率为优化目标，得到最佳制备条件为温度30℃、壳聚糖浓度5.0%、L-苯丙氨酸浓度1.0%、氢氧化钠浓度0.75 mol/L、电压10 kV、转速450 r/min、下滴高度11 cm。在此条件下制得的微囊包封率为66.9%，载药量为0.58%。L-苯丙氨酸微囊化后稳定性有较大的提高。微囊表面布满小孔，有利于L-苯丙氨酸的缓释。
Abstract:Chitosan-L-phenylalanine microcapsules were prepared by high-voltage electrostatic field method.Taking encapsulation efficiency as optimization object，the optimum conditions for the preparation were temperature 30℃，chitosan concentration 5.0%，and L-phenylalanine acid concentration 1.0%，sodium hydroxide concentration 0.75 mol/L，voltage 10 kV，speed 450 r/min，the dropping height was 11 cm.The encapsulation efficiency was 66.9%，and the drug loading was 0.58%.The stability of L-phenylalanine after microencapsulation was greatly improved.
keywords: L-phenylalanine chitosan microcapsule high voltage electrostatic field encapsulation efficiency
文章编号：201824007 中图分类号： 文献标志码：
基金项目:
引用文本：
津ICP备20000603号-1