Abstract:The ultrasonic microwave synergistic method was used to extract the anthocyanin from Hibiscus sabdariffa.The effects of ultrasonic power，extraction temperature，microwave power，extraction time，ethanol volume fraction and liquid/solid ratio on the yield of anthocyanin were investigated.The response surface methodology was used to optimize the extraction process of Hibiscus sabdariffa anthocyanin，the best optimal parameters that ultrasound power was 350 W，extraction temperature was 50℃，microwave power was 279 W，extraction time was 18 min ，ethanol volume fraction was 60%，and the ratio of liquid/solid was 36 ∶1（mL/g），were produced through four factors and three levels of response surface optimization experiments.The actual value obtained from 3 parallel experiments was 787.56 mg/100 g，which was similar to the predicted value of 786.556 mg/100 g，which proved that the test model was feasible.