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食品研究与开发:2018,39(21):27-32
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俄色叶水提物对糖尿病模型小鼠降血糖作用的研究
任军辉,索朗欧珠,邵妍丽,德央,丁云春
(1.西藏职业技术学院,西藏拉萨850000;2.西藏自治区罗布林卡管理处,西藏拉萨850000)
Investigation of Hypoglycemic Effect of Water-extraction from Malus toringoides Leaves in Diabetic Mice
REN Jun-hui,SUOLANG Ou-zhu,SHAO Yan-li,DE Yang,DING Yun-chun
(1.Tibet Vocational Technical College,Lhasa 850000,Tibet,China;2.Administrative Office of Norbulingka,Tibet,Lhasa 850000,Tibet,China)
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投稿时间:2018-05-16    
中文摘要: 考察俄色叶水提物对糖尿病模型小鼠的降血糖作用。选取50只糖尿病模型小鼠随机分为俄色叶水提物低、中、高剂量组[130、260、520 mg/(kg·d)]、盐酸二甲双胍组[260 mg/(kg·d)]、模型组,并设立空白组,连续灌胃21 d。测定其体重、空腹血糖、糖耐量、血清超氧化物歧化酶(superoxide dismutase,SOD)、一氧化氮(nitric oxide,NO)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)含量、肝脏丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)含量。结果显示,俄色叶水提物可有效恢复糖尿病小鼠体重增长,降低血糖水平,提高糖耐受量,且呈现一定的剂量关系,还可提高SOD、GSH-Px活性,降低NO、MDA、TG、TC含量,对AST、ALT等无影响。俄色叶水提物对糖尿病模型小鼠有降血糖作用,其作用与抗氧化应激反应有关,且对肝功无影响。
中文关键词: 俄色叶  水提物  四氧嘧啶  小鼠  降血糖
Abstract:The hypoglycemic effect of water-extraction from Malus toringoides leaves was investigated in diabetic mice induced by alloxan.The 50 diabetic mice were randomly divided into low,medium and high dose of water-extraction groups[130,260,520 mg/(kg·d)],metformin hydrochloride group[260 mg/(kg·d)],model group and blank group,then the mice were continuously received the intragastric administration for 21 days.The body weight,fasting blood glucose,glucose tolerance,the content of superoxide dismutase(SOD),nitric oxide
文章编号:201821005     中图分类号:    文献标志码:
基金项目:西藏自治区自然科学基金项目(XZ2017ZRG-109)
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