Abstract:Anti-fatigue effects of Panax ginseng Lepidium meyenii（PL）tablet was studied by exercise mice model experiment.Mice were randomly divided into 3 groups：low-dose，medium-and high-dose PL tablettreated groups and control group.Autonomic activities number，rotating time，running time and exhaustive swimming time were determined to evaluate the endurance effect of PL tablet，the levels of adenosine triphosphate（ATP），total superoxide dismutase（T-SOD），glutathione reductase（GSH-Px）and the content of testosterone（T），estradiol（E2）and progesterone（PROG）before and after swimming immediately in blood and liver samples were detected to reaserch the anti-fatigue mechanism of PL tablet.Autonomic activity test showed that PL tablet did not damage the central nervous system of mice.Compared with the control group，PL tablet significantly prolonged the time of rod，endurance and weight-bearing swimming.PL tablet significantly increased ATP levels in serum after swimming compared with the control group，as well as significantly increased T-SOD and GSH-Px levels in serum and liver compared with the control group，PL tablet significantly improved the sexhormone T and PROG levels of male and female mice.Combined with the above experimental results，it can be concluded that PL tablet had improved exercise tolerance and relieve fatigue effect，this may be related to its inhibition effect on lipid peroxidation.，this may be related to its inhibition effect on lipid peroxidation.