Abstract:Seabuckthorn pomace was selected as raw material，the total flavone effervescent tablet was prepared by using the extracted coarse flavone powder，sweetener，effervescent agent and binder.The disintegration of the single factor test and proportion test of effervescent tablets were selected，the results showed that the better conditions for disintegration of effervescent tablets were：ingredients for total flavone powder and effervescent agents，sweeteners and accessories for the 2%-3%polyethylene glycol 6000.Then the response surface analysis of the formulation was carried out according to the optimum result.The optimum formula for the total flavonoids powder in each effervescent tablet was 60.1%，sweetener dosage was 8.4%，effervescent agent was 29.5%，the dosage of PEG 6000 was 2%，the prediction of the product sensory score reached 79 points，the actual sensory score was 82 points，the prediction accuracy was 96.3%.