Abstract:The polysaccharide from Lily was extracted by ultrasonic-assisted extraction （UAE）method using flesh Lily in Yixing as raw materials.Firstly，the effects of the four main factors（ ultrasonic power，ultrasonic temperature，ultrasonic time and ratio of water to material）on the yield of Lily polysaccharide was discussed through single-factor experiments.The extraction technological condition of Lily polysaccharide was optimized with response surface method after single－factor test.Results showed that the maximum extraction yield of Lily polysaccharide was obtained at ultrasonic power 176 W，extraction temperature 52℃，extraction time 30 min and ratio of water to material 15 ∶1（mL/g）.Under this condition，the yield of Lily polysaccharide with ultrasonic extraction was the best of 12.37%，and the difference was not significant compared with the theoretical prediction.The mathematical model obtained in this experiment could accurately predict the yield of polysaccharide from Lily.This results will provide an experimental basis to further develop the resources of Lily in Yixing.