Abstract:In order to develop a new product of chewing gum， Wasabi japonica roots was taken as raw material with adds gum base， xylitol， sorbitol and distilled water to produce a new chewing gum. The formulation was based on orthogonal experiment. The result from the single and orthogonal experiments， showed that the optimal formula were as follows： gum base 30 g， sugar alcohol mixture 45 g， Wasabi japonica β-CD inclution 3.0 g， distilled water 15 mL. The chewing gum had wasabi's spice notes and good taste and had prevention and control efficacy of the oral diseases such as oral ulcer， gingivitis and bad breath. Not only conforms to the future devel－ oping direction treatment of chewing gum， but also opens up a new path for the development of horseradish prod－ ucts.