Abstract:Ginseng has a variety of pharmacological effects（such as anti-cancer， anti-cancer， anti-aging），in addition to the ginseng polysaccharide， ginseng peptides and other compounds， main active ingredient is gin－ senosides. Thus， directional transformation of ginsenosides is used to hydrolyze glycosidic bonds by chemical， enzymatic and microbiological methods， reducing the number of glycosylation of the high levels of ginsenosides， acquire rare ginsenosides of higher pharmacological activity（such as C-K， F2， etc.）， and improve the econom－ ic value of ginseng. In this paper， the current status and progress of research on microbial transformation of gin－ senosides were summarized， which provided the basis for further study of the microbial transformation of gin－ senosides.