Abstract:To observe the effects of phenolic extracts from walnut（Juglans regia L.） kernel pellicle（EWP） byproduct on cerebral injury aging mice induced by D-galactose. Male ICR mice （n=60） were randomly divided into five groups of 12 each. Hypodermic injection of D-gal at the dose of 120 mg/（kg·bw·d）， low， middle and high groups gived EWP by 200， 400， 800 mg/（kg·bw·d） respectively， while the control group gavage equiva－ lent normal saline. After 7 weeks， the behavior changes were investigated by open-field test，tightrope test and balancing beam test between dosage groups and normal controls. After 8 weeks， the contents of malonialdehyde （MDA）， the activities of superoxide dismutase （SOD）， catalase （CAT）， glutathione peroxidase （GSH-Px） and total antioxidant capacity（T-AOC） in brain were observed. The result showed that EWP could significantly improve the mice's ability to exercise and explore， enhance the excitability and the adaptability to the environ－ ment. At the same time， it significantly increased activities of the antioxidant enzymes by enhanced activities of SOD， GSH-Px， T-AOC as compared to model group. This indicated that EWP could reduce the action retarda－ tion induced by D-galactose， and could reduce the oxidative damage in the brain of mice.