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食品研究与开发:2017,38(11):181-184
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菌株QS670制备发酵乳大鼠体内降压效果研究
双全,许伟瀚,韩剑骄,吴楠
(内蒙古农业大学 食品科学与工程学院,内蒙古 呼和浩特 010018)
Antihypertensive Effects of Yogurt Fermented with Lactobacillus plantarum QS670 in Spontaneously Hypertensive Rats
Shuang-quan, XU Wei-han,HAN Jian-jiao,WU Nan
(College of Food Science and Engineering,Inner Mongolia Agricultural University, Huhhot 010018, Inner Mongolia, China)
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投稿时间:2016-08-31    
中文摘要: 研究植物乳杆菌 QS670 制备发酵乳对自发性高血压大鼠(SHR)的降压效果,并与京都 Wistar 大鼠(WKY)的 作用效果作比较。分别以 5、10、20 mL/kg 剂量的菌株 QS670 制备发酵乳一次性给药后,每隔 2 h 测量大鼠血压,连续 测量 10 h;长期试验持续 4 周,每天 10 mL/kg 灌胃一次,每周测量血压一次。SHR 大鼠给予菌株 QS670 制备发酵乳 后,血压均显著下降,并均在灌胃 4 h 后达到最低值,血压下降最大幅度为(2.33±0.54) kPa;长期灌胃植物乳杆菌 QS670 制备发酵乳可使 SHR 大鼠血压下降明显,且降压效果稳定。
Abstract:To study the antihypertensive effect of the yogurt fermented with Lactobacillus plantarum QS670 on spontaneously hypertensive rats(SHR)and compared with the normal blood pressure Wistar rats(WKY). A sin- gle medication at different doses of the yogurt fermented with Lactobacillus plantarum QS670 (5, 10, 20 mL/kg) were intragastric administered. After administration, blood pressure was measured every 2 h continuously for 10 h, while long-term medcation lasted for 4 weeks , offered 10 mL/kg once a day and the blood pressure was determined every other week. After the administrations of the yogurt fermented with Lactobacillus plantarum QS670 , the blood pressure all decreased significantly in SHR, and reached the lowest value in two-hours'gav- age, which was reduced by(2.33±0.54) kPa. Long-term gavage of Lactobacillus plantarum QS670 can signifi- cantly decrease SHR blood pressure and had a stable antihypertensive effect.
文章编号:201711040     中图分类号:    文献标志码:A
基金项目:国家自然科学基金(31460443);内蒙古自治区自然科学基 金(2016MS0338)
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