Abstract:A novel method was established to determination five kinds of harmful elements in vegetable by in－ ductively coupled plasma mass spectrometry（ICP-MS） together with microwave sample digestion method. And72Ge、115In、209Bi and 45Sc were selected as the internal standard elements to overcome the matrix effects and instru－ ment fluctuations effectively. Satisfactory linearity of standard curves was obtained with elemental correlation coefficients over 0.999. The detection limits of Pb， Cd， As， Tl and Al were 0.08， 0.03， 0.3， 0.04， 60 μg/kg， and the recoveries of samples were 80 %-120 %. This method was applied to the determination of vegetable ref－ erence samples with satisfactory results.