Abstract:In this paper we investigated the hypoglycemic effect of wild Acanthopanax and Chinese wolfberry fruit towards diabetic mice. We made 50 diabetic mice randomly divided into the following groups： Acan -thopanax group（5 g/kg）， Chinese wolfberry fruit group（5 g/kg）， Acanthopanax and Chinese wolfberry fruit（1 ∶ 1） group， alloxan model group and the blank control group. The mice were continouslyreceivedthe intragastri－ cadministration for 15 days and measured the content of fasting blood glucose， insulin， serum SOD， serum MDA， then we conductedthe oral glucose tolerance experiment on the mice. Results： Acanthopanax and Chi－ nese wolfberry fruit group and alloxan model group significantly reduced the fasting blood glucose in diabetic mice， increasing the level of insulin and glucose tolerance and significantly improving the SOD activity in serum of diabetic mice， mean while the content of MDA was reduced. Changbai Mountain wild Acanthopanax com－ bined with fruit of Chinese wolfberry has a hypoglycemic effect on diabetic mice.