Abstract:External standard method and QAMS were compared in measure four constituents content of honey－ suckle. External standard method was applied to determine the contents of four constituent， chlorogenic acid and rutin were used as the reference， the calibration factor of other constituents to that of chlorogenic acid and rutin were calculated respectively to get each relative calibration factor. And the contents of the active con－ stituents were calculated by the relative calibration factor to realize QAMS. At the same time， the external stan－ dard method was used to detect the contents of the four constituents， comparing the two methods to validate the accuracy and feasibility of the new method. QAMS was applied in different types compounds of different regions honeysuckle have significant difference， QAMS was applied in same types compounds of different regions hon－ eysuckle have no significant difference. QAMS was not feasible and accurate to apply in different types of com－ pound content in honeysuckle， so application of QAMS has definite localization.