Abstract:The extraction technology of proanthocyanidins from Fructus Ligustri Lucidi skin was optimized by microwave-assisted. The single factor and orthogonal test was used to study the effects of proanthocyanidins ex－ traction yield， including hydrochloric acid content， ethanol concentration， material -liquid ratio， ultrasonic time and extraction temperature. The results showed that the optimum extraction technology were∶ hydrochloric acid 1 %， ethanol 60 %， material-liquid ratio 1 ∶ 10 （g/mL）， ultrasonic time 20 min and extraction tempera－ ture 50 ℃. The proanthocyanidins extraction yield was 4.4 % at the best process. The process was simple and short time， and the test provided referential basis for the further research.