Abstract:This study was performed to determinate immunoregulatory activity of the mixture of polysaccharides of Lentinus edodes， Ganoderma luncidum and Pleurotus ostreatus. Splenic lymphocyte immunity： in the situa－ tion of low doses， polysaccharides compounds significantly promoted the splenic lymphocyte immunity in mice.Non-special immunity： polysaccharides compounds only at both medium and high doses significantly promoted the non -special immunity in mice. Humoral immunity： in the situation of low doses， polysaccharides com－ pounds significantly promoted the humoral immunity in mice. All of the animal test showed that edible fungus polysaccharides compounds significantly promoted the immunologic function in mice.at moderate dose compar－ ing with single edible fungus polysaccharide.