Abstract:To establish a solid phase extraction - high performance liquid chromatography （HPLC） method for simultaneous determination anilazine and iprodione pesticides residue analysis method in cucumber and tomato， the samples were extracted by acetonitrile homogenizing dehydration method， purified by solid phase extraction （SPE）， while the concentrated liquid was separated and detected by liquid chromatography and quantified by external standard method. The added recovery experiments were also carried out in which the added concentra－ tion was 0.1，0.5，1.0 mg/kg respectively， 2 kinds of pesticides anilazine and iprodione rate of recovery was in the range of 82.5 % to 102.8 %， the standard deviation （RSD）was in the range of 2.95 % to 8.68 %， the mini－ mum detection limit of 0.02 mg/kg. This method can meet the requirements of the determination for anilazine and iprodione pesticides residue in cucumber and tomato.