Abstract:Optimization of water extraction total flavonoids from Ficus Tikoua Bur.by response surface methodology was studied.Based on the single-factor test analysis，the Plackett-Burman experimental design and steepest ascent design，while take extracted amount of total flavonoids as the response value，response surface method was applied to analyze the influence of various factors and their interaction on the extraction of total flavonoids，select an optimized progress to extract total flavonoids from Ficus Tikoua Bur..The optimal water extraction of total flavonoids from Ficus Tikoua Bur.progress conditions were solid-liquid ratio 1∶50（g/mL）；soak time 50 min，extraction temperature 60℃；extraction time 50 min.Under these conditions，extracted amount of total flavonoids from Ficus Tikoua Bur.can reach 25.62 mg/g.