Abstract:Perfluorinated compounds （PFCs）are fluorinated aliphatic compounds that are widely used in in－dustry and life.PFCs are getting more and more attention because their potential persistence，bioaccumulation and toxicity.Due to their wide distribution，PFCs has been harmful to human food safety.This paper mainly introduces the latest development of the sample pretreatment methods for PFCs in different foodstuffs.The main pretreatment methods are liquid-liquid extraction and liquid-solid extraction，and solid phase extraction is used to reduce the influence of complex foodstuffs mechanism on the accuracy of the determination of PFCs.Since the concentration of PFCs in foodstuffs is in trace levels，improving the simplicity and accuracy of PFCs pretreatment in foodstuffs are very important.