Abstract:Response surface method was applied to optimize the ultrasonic extraction conditions for preparing totalflavonoids from Limonium gmelinii（Wiid）Kuntze.The influence factors ofultrasonic extraction were evaluated using the Box-Behnken central component experiments and analyzed by RSM.The optimum extraction conditions were confirmed as follows：extraction time of 30 min，ratio ofliquid to solid 17∶1（mL/g），concentration ofethanol65%.The predicted yield of generalflavonoids was 2.15%.Validation experiments were carried out three times at the optimal conditions，the average yield of general flavonoids was 2.45%.The relative error between actualvalues and predicted values is 0.6%.Itfitwellthe predicted values.The developed regression equation can be wellfitted with experimentalresults and used for actualprediction，and italso provided reference for the extraction oftotalflavonoids from L.gmelini i.