Abstract:A rapid，simple，efficient and accurate method based on HPLC was developed for determination of acesulfame potassium，benzoic acid，sorbic acid，sodium saccharin and dehydroacetic acid in moon cake.The moon cake sample was ultrasonically extracted by ultrasonic extraction with ultrapure water，the supernatant was constant volume after filtered with ltrapure water，then the sample was tested after filtered by 0.45 μm microporous membrane.The linear range of the method was 1.00 μg/mL-50.00 μg/mL with a correlation coefficient of 0.995.The average recovery among 90%and 100%，relative standard deviations（RSD）within 5%，which indicated the research method was accurate and reliable.