Abstract:α-acids is the main component of hops extracts and also the main element for bitterness of beer.The isomeric compound of α-acids could improve the stabilily of beer foam and the quality of beer.The influencing factors on isomerization of α-acids for the types of catalyst and the amount of catalyst，heating time，temperature and pH were choiced by single factor experiment.The result showed that the optimal conditions of the iso merization of α-acids was obtained respectively，i.e.，MgCl2as the catalyst for the isomerization of α-acids，4%of mass fraction of catalyst，180 min of heating time，80℃of heating temperature，and pH 10.05，respectively.The isomerizating efficiency of α-acid was 78.6%.It was an very important that the optimal conditions of the isomerization of α-acids was obtained for exploring hop products in industry and raising isomerization rate of α-acids.