Abstract:To develop a production technology of Shuangye granule. Persimmon leaf and hawthorn leaf were used as raw material to prepare Shuangye granule， and the optimum extraction and production techniques were be selected by L9（34） orthogonal test. The optimum extraction condition of Shuangye preparation was： the extraction solvent was purified water， extraction time 1.5 h， extraction solid-liquid ratio 1 ∶ 8 （g/mL）， extraction times 3； and the optimum production technology was： the excipients were starch， dextrin and powdered sugar， excipients radio 1 ∶ 1 ∶ 1（g ∶ g ∶ g）， the wetter was 65 % ethanol. The granule with stable quality and easy taking can be prepare by the optimal production technology.