Abstract:To investigate the antitumor effects of coarse flavones extract from longan shell in vitro and vivo. In vitro， MTT method was used to detect the inhibitory effect of coarse flavones extract from longan shell on EC109 and HepG2. In vivo， S180-bearing mice were given coarse flavones extract from longan shell and the tumor inhibitory rates of mice were detected in coarse flavones extract （100，200，300 mg/kg） groups and coarse flavones extract combined with CTX （20 mg/kg） groups. The thymus index， spleen index， macrophage phagocytic rate and phagocytic index were calculated in coarse flavones extract combined with CTX proups. ELISA method was used to detect the the levels of serum TNF-α in coarse flavones extract groups. In vitro， the results showed that the coarse flavones extract of longan shell significantly inhibited the growth of EC109 and HepG2 cells， and showed a certain concentration dependence.In vivo， the results showed that the coarse flavones extract of longan shell （low）， （middle） and （high） group could inhibit the growth of S180 sarcoma， and the inhibition rate was 28.24 %， 44.91 % and 60.65 % respectively. The tumor inhibitory rates of coarse flavones extract combined with CTX were 53.7 % ，65.74 % ，70.37 % ， which were higher than that of CTX administration alone （47.69 % ）. Compared with those in CTX group，the thymus index， spleen index， macrophage phagocytic rate and phagocytic index were significantly elevated in all coarse flavones extract combined with CTX groups. Compared with the model group， the extract （low）， （middle） and （high） groups did not increase the level of serum TNF-αin mice. The coarse flavones extract from exocarp of longan had antitumor effect and could inhibit the growth of S180 tumor and and had synergistic attenuation effect of CTX.