Abstract:To investigate the effects of Lonicera caerulea compound preparation（LAC）on blood lipid levels and intestinal flora in the rat model of hyperlipidemia，thirty SD rats were randomized into six groups：blank control，model（hyperlipidemia），simvastatin（positive control），and low-，medium-，and high-dose LAC groups.After 28 days of administration，the body mass and physiological and biochemical indexes were measured，and the intestinal flora was analyzed.The results showed that compared with the model group，the LAC groups with different doses showed recovery to varying degrees in terms of the levels of four blood lipids，organ tissue morphology，antioxidant function，and the levels of lipid metabolism-related enzymes and markers.Additionally，each administration group showed increased relative abundance of beneficial bacteria such as Romboutsia，Lactobacillus，and Blautia in the intestinal flora to different extents，which improved the richness of beneficial bacteria in the intestinal environment，showing significant differences from the intestinal flora of rats in the model group.Therefore，this liquid preparation can significantly improve the blood lipid levels of hyperlipidemic rats in many aspects，regulate intestinal flora disorders，and increase the relative abundance of beneficial bacterial genera.