Abstract:Polygonati Rhizoma meal replacement powder giving the sense of satiety and with low glycemic index （GI） was developed with Polygonati Rhizoma as the main raw material. The ratio of raw materials was screened by single factor tests， and the response surface method was employed to optimize the formula of the meal replacement powder. The optimized formula was composed of 7.40 g Polygonati Rhizoma powder， 5.94 g plantago seed husk powder，5.06 g Crataegi Fructus powder， 4 g chia seeds powder， 6 g oat powder， and 0.025 g mogroside. The quality of the meal replacement powder was evaluated in terms of brewing characteristics， moisture content， color parameters， regulation of postprandial blood glucose， and satiety index. The product showed the dispersion stability index of 2.41%， the solubility index of 39.0%， and the average whiteness of 40.17. The average GI of 24.21 indicated that the meal replacement powder was a low-GI food. The meal replacement powder gave the peak sense of satiety about 15 min after intake and maintained a good sense of satiety within 1 h. The sense of satiety then gradually decreased and returned to the initial state after 2 h.