Abstract:To investigate the effect of inulin or compound inulin dietary fiber on inflammatory injury，oxidative stress，and intestinal flora of mice with pulmonary fibrosis，male C57BL/6 mice were randomly divided into normal （NC） group，model （MC） group，inulin （IN） group，compound inulin （CIN） group，and pirfenidone （PFD）group. Mice models of pulmonary fibrosis were established by endotracheal injection of bleomycin，and then the NC and MC were given normal saline. IN was given 5.00 g/kg inulin，and CIN was given 5.00 g/kg compound inulin. PFD was given 300.00 mg/kg pirfenidone. After 28 d，to evaluate the effects of inulin and compound inulin on physiological and biochemical properties and intestinal flora structure of mice with pulmonary fibrosis，the pulmonary histopathology，inflammatory factor，oxidative stress，and intestinal flora were analyzed.The results showed that compared to MC，inulin and compound inulin could decrease inflammatory infiltration and fibrous hyperplasia of lung tissue，significantly decreased the level of tumor necrosis factor-α，interleukin-6，and interleukin-1 β （p＜0.05），bolstered the total antioxidant capacity，and enhanced the activity of superoxide dismutase. They could decrease the level of malondialdehyde，alleviate intestinal flora disturbance，promote the proliferation of Dubosiella，norank_f__Muribaculaceae，and Akkermansia，and inhibit the proliferation of Lleibaterium. In conclusion，inulin or compound inulin dietary fiber could improve inflammatory damage and oxidative stress of mice with pulmonary fibrosis and regulate intestinal flora disturbance.