Abstract:As an important microorganism in the fermentation industry，Saccharomyces cerevisiae is widely used in brewing and baking.However，during the production process，yeast cells often face various environmental stresses，including ethanol stress in brewing as well as freezing and high osmotic stresses in baking.These conditions will inhibit the growth and metabolic ability of yeast cells，reducing their fermentation efficiency.Trehalose，as a vital cytoprotective agent，can protect cells by maintaining the structural stability of cell membranes and proteins under stress conditions such as cold，dry，and oxidative ones.In S.cerevisiae，alpha-glucoside transporter（Agt1）is a hydrion-dependent trehalose transporter protein that protects cells by transporting trehalose to the lipid bilayer during various stress responses.This study reviewed the stress response mechanisms of trehalose in S.cerevisiae and the research progress related to Agt1.It is expected to lay a theoretical foundation for screening and constructing high-yield and high-tolerance industrial S.cerevisiae strains.