Abstract:Polyphenols，secondary metabolites of plants，are ubiquitous in fruits，vegetables，tea，and cereals.Studies have shown that plant polyphenols can directly or stimulate the production of metabolites to indirectly regulate the intestinal flora structure，thus playing a role in stabilizing blood glucose and lipid levels，improving insulin sensitivity and intestinal function，and regulating glucose and lipid metabolism.The studies about the interactions between plant polyphenols and intestinal flora were reviewed.The mechanisms of plant polyphenols in improving intestinal barrier function and recovering glucose and lipid metabolism disorders by regulating intestinal flora were summarized.Furthermore，the application of plant polyphenols was prospected.The review underpins further development of plant polyphenols and provides references for improving intestinal health and preventing metabolic diseases such as diabetes and obesity.