Abstract:7 kinds of shiitakes with different textures were extracted assisted by ultrasonic with 5% ethanol solution. The content of polysaccharides，eritadenine，total polyphenols，and total flavonoids in shiitakes was determined. The antioxidant activity and lipid-lowering function of 7 kinds of shiitake extracts in vitro were evaluated by DPPH and ABTS+free radical scavenging activities and the inhibition for pancreatic lipase activity.Finally，the possible key active components were determined by the content of target active components and the correlation analysis between antioxidation and lipid-lowering activity in vitro.The results showed that there were some differences in the content of active components and the in vitro antioxidant and lipid-lowering abilities of shiitakes with different textures.The content of total polyphenols，total flavonoids，crude polysaccharides，and eritadenine in the Ban shiitake was the highest，which was 1.54，0.83，63.40 μg/mL，and 24.17 μg/mL，respectively.The free radical scavenging rates of DPPH and ABTS+and the inhibition of pancreatic lipase were 88.20%，99.89% and 41.77%，respectively.The results of correlation analysis showed that the DPPH free radical scavenging ability and pancreatic lipase inhibition of 7 kinds of shiitake extracts with different textures were significantly and positively correlated with the content of eritadenine.