Abstract:The ultrasonic assisted extraction method was adopted to study the extraction process of Polygonatum cyrtonema Hua polysaccharides.On the basis of single-factor experiment and with the yield of polysaccharides as the index，the extraction parameters of solid-liquid ratio，ultrasonic power，ultrasonic time and ultrasonic temperature were optimized by response surface method；The formulation of polysaccharides buccal tablets of P.cyrtonema Hua was optimized by response surface design，the comprehensive score was used as the index to obtain the optimal addictive amount of fillers，flavor enhancers and lubricants as well as the volume fraction of moistening agents for granulation on the basis of single-factor experiment.The results showed that the optimum ultrasonic assisted extraction method parameters were as follows：the solid-liquid ratio of 1∶40（g/mL），ultrasonic power of 270 W，ultrasonic temperature of 71℃and ultrasonic time of 49 min.Under this condition，the yield of P.cyrtonema Hua polysaccharides was（25.07±0.15）%.The optimal formulation of polysaccharides buccal tablets of P. cyrtonema Hua was as follows：19.91% fillers （mannitol:microcrystalline cellulose=3 ∶1，mass/ratio），14.55% xylitol（flavor enhancer），5.04% citric acid（flavor enhancer），and 0.5% magnesium stearate（lubricant）were added，and the volume fraction of ethanol（moistening agent）was 85%.The extraction of P.cyrtonema Hua polysaccharides and the preparation process of its buccal tablets are stable and controllable. The content of polygonum polysaccharides in the polysaccharides buccal tablets of P. cyrtonema Hua is not less than 0.28 g/tablet，and the disintegration time and fragility meet the quality requirements.The tablets had uniform light yellow color as well as suitable sweet and sour taste.