Abstract:Response surface methodology was used to optimize the ultrasonic extraction process of saponins from Momordica charantia，and the inhibitory activity of the extract on α -glucosidase under the optimal extraction process conditions was investigated.The experimental results showed that the optimal extraction conditions for ultrasonic extraction of saponins from Momordica charantia were solid-liquid ratio 1 ∶15（g/mL），ethanol concentration 75% ，ultrasonic time 95 min，extraction temperature 50℃.Under such conditions，the extraction rate of saponins from Momordica charantia was up to 2.21% ，and the IC50value against α-glucosidase was 5.48 mg/mL.