Abstract:This experiment was conducted to optimize the formulation of Pyrus bretschneideri Rehd.dietary fiber chewable tablets and investigate its in vitro hypoglycemic activity.P.bretschneideri dietary fiber powder was used as the main raw material and prepared by a mixed enzyme method with a yield of（66.90±2.24）%.Using the direct powder compression method，the sensory scores as well as differences in tablet weight，hardness，disintegration time limit，and crispness were evaluated.The optimal formulation was determined based on single-factor and Box-Behnken response surface optimization test results and by evaluating its in vitro hypoglycemic activity.The results showed that the best formulation of P.bretschneideri dietary fiber chewable tablets resulted from the addition of 14.62% of P.bretschneideri dietary fiber powder，14.08% of maltodextrin，and 20.85% of granulated white sugar.As time progressed，the glucose adsorption capacity of the chewable tablet was increase and found to be（34.66±0.92）mg/g，causing in vitro hypoglycemic activity.