Abstract:Bee pollen is a dietary supplement.However，the allergenicity of bee pollen with botanical origin becomes a common challenge to the safety，processing，and utilization of bee pollen.A number of clinical allergy cases caused by the consumption of bee pollen or its formulations have been reported，while little is known about the allergenic mechanism.Thus，the studies about bee pollen allergy，allergen isolation and identification，evaluation of allergenic mechanisms，and allergen elimination techniques were reviewed.Additionally，this paper prospected the future research orientation of bee pollen allergy，aiming to provide a foundation for the safe production，development，and utilization of bee pollen.