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投稿时间:2021-11-18
投稿时间:2021-11-18
中文摘要: 以D-半乳糖致衰老小鼠造模,采用水迷宫及旷场实验行为学指标,结合脏器指数及血清、脑组织的总抗氧化能力(total antioxidant capacity,TAOC)、超氧化物歧化酶(superoxide dismutase,SOD)、过氧化氢酶(catalase,CAT)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)的活性指标,及丙二醛(malonaldehyde,MDA)含量,考察坦洋工夫红茶多糖(Tanyang Congou black tea,TBTP)对D-半乳糖致衰老模型小鼠的学习记忆能力的影响。结果表明,TBTP可显著改善衰老模型小鼠的脏器指数,有效提升血清及脑组织的TAOC、SOD、CAT和GSH-Px活力,水迷宫实验搜台潜伏期显著缩短(P<0.01),空间探索能力增强(P<0.01),旷场实验移动路程长度和直立次数显著增加(P<0.01)。TBTP表现出较强的抗氧化活性,提升了机体抗氧化能力。
中文关键词: 坦洋工夫红茶多糖 D-半乳糖致衰老小鼠模型 抗氧化能力 行为学实验 脏器指数
Abstract:With the aging mouse model induced by D-galactose,the effect of polysaccharide from Tanyang Congou black tea(TBTP)on the learning and memory ability of mouse by water maze test and open field test were studied.The mouse body weight and organ indexes,total antioxidant capacity(TAOC),malonaldehyde(MDA)content,and the activities of superoxide dismutase(SOD),catalase(CAT),and glutathione peroxidase(GSHPx)in liver and brain tissues were analyzed.The results showed that TBTP significantly improved the general state and organ indexes of the aging mice,increased the TAOC and activities of SOD,CAT,and GSH-Px in serum,shortened the latency and searching distance in water maze test(P<0.01),and increased the average travel distance and rearings in open field test(P<0.01).TBTP could significantly alleviate the loss of memory and the declines in learning and response ability of D-galactose-induced aging mice,showing a strong antioxidant activity.
keywords: polysaccharide from Tanyang Congou black tea(TBTP) D-galactose-induced aging mouse model antioxidant activity behavioral test organ index
文章编号:202208009 中图分类号: 文献标志码:
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作者 | 单位 |
李达,刘鹏,纪海玉,贾晓昱,田凌 | 天津现代职业技术学院,生物工程学院,天津 300451;天津科技大学食品科学与工程学院,天津 300457;天津市农业科学院农产品保鲜与加工技术研究所,天津 300384;唐山市盛川农产品股份有限公司,河北 唐山 064105 |
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