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投稿时间：2021-03-30
投稿时间：2021-03-30
中文摘要: 以二氢杨梅素（dihydromyricetin，DMY）-银离子（DMY-Ag+）纳米乳液体系（以下简称乳液）为研究对象，并探究其对浮游态和生物被膜态白色念珠菌的生长抑制情况。在二氢杨梅素和银离子共同作用下，浮游态白色念珠菌和生物被膜态白色念珠菌的生长增殖均受到纳米乳液的抑制，乳液通过改变细胞表面的特性，破坏菌的完整性进而影响其正常的生命活性，影响其生长和增殖，从而抑制浮游态和生物被膜态细菌的活性。乳液在抑制浮游态菌体和生物被膜态菌体生长方面具有协同作用，有望开发为一种有效的抗菌剂。
Abstract:The effect of a dihydromyricetin-silver ion （DMY-Ag+）nanoemulsion system on the growth of planktonic and biofilm forms of Candida albicans was examined.The growth and proliferation of both planktonic and biofilm C.albicans were inhibited due to the combined effect of DMY-Ag+.The inhibitory activity was due to altered cell surface properties，which destroyed the integrity of the bacteria and thus affected normal vital activities in growth and proliferation.The nanoemulsion synergistically inhibited the growth of both planktonic and biofilm C.albicans.The findings indicate the potential of the DMY-Ag+nanoemulsion as an effective antimicrobial agent.
keywords: nano-emulsion dihydromyricetin Ag+ Candida albicans biofilm
文章编号：202205026 中图分类号： 文献标志码：
基金项目:国家自然科学基金（21706037）
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