Abstract:To study the effect of polypeptides from fish roes on improving memory.A total of 144 specificpathogen-free，Kunming female mice were divided into 3 test groups with 48 mice in each group—low-，medium-，and high-dose polypeptides from fish roes groups and the respective blank control groups.Polypeptides from fish roes at 0.17，0.33，and 1.00 g per kg body weight per day were intragastrically administered to the low-，medium-，and high-dose groups，respectively，the blank control groups did not receive any polypeptides.After treatment for 41 d，step-down，shuttle box，and Morris water maze tests were performed on day 42 to compare the responses of the mice in the different treatment groups.The step-down latency of mice in the highdose group was significantly prolonged compared with that of mice in the control group （p＜0.05）.The active avoidance time in the medium-dose group was significantly shorter than that in the control group （p＜0.05）.No significant difference was observed in passive avoidance time between each dose group and the control group（p＞0.05）.The number of times of crossing the platform in the medium-dose group was significantly higher than that in the control group （p＜0.05）.The findings suggest that supplementation with polypeptides from fish roes can improve the memory skills of mice and has certain development potential.